TBTB-500
01 TRENDING TOPICS
02 RESEARCH FEED
Microglial Labeling in Mouse Spinal Cord Injury: A Review of Timing, Efficacy, and Specificity.
Traumatic spinal cord injury (SCI) is a complex and disabling condition with no curative therapy currently available. The mechanical damage of the primary injury phase is followed and exacerbated by a secondary injury…
Glia · 2026Heterogeneous nuclear ribonucleoprotein A1 as a candidate associated with pulmonary vascular remodeling in pulmonary arterial hypertension.
RationaleAlthough plexiform lesion (PL) formation in severe pulmonary arterial hypertension (PAH) is a therapeutic target, the mechanisms underlying their formation have not been fully elucidated.ObjectiveTo identify…
Journal of molecular and cellular cardiology plus · 2026Structural and Functional Characterisation of a Metagenome-Derived CYP108D18 Reveals an Unusual Dioxygen-Bound State and Selective Hydrocarbon Hydroxylation.
Cytochrome P450 enzymes form a large superfamily of monooxygenases capable of oxidising diverse substrates. Among them, members of the CYP108 family are recognised for their role in monoterpenoid oxidation. In this…
Microbial biotechnology · 2026Mitochondria-Targeted Nanotherapeutics: A Promising Strategy in Modulating Mitochondrial Function, Transfer, and Transplantation.
Mitochondria, as organelles with a critical role in maintaining cellular activities, are also vulnerable to dysfunction, which contributes substantially to the pathogenesis of various systemic diseases. Nanomaterials,…
Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026New pharmacological and biotechnological approaches for the treatment of neurotrophic keratopathy: From growth factors to gene therapy.
Neurotrophic keratopathy (NK) is a serious ocular surface disease that develops due to a reduction or loss of corneal innervation. Conventional therapeutic approaches, such as the use of artificial tears and autologous…
Indian journal of ophthalmology · 2026Contribution of p38 MAPK in liver fibrosis: An overview of mechanisms, signaling pathways, and therapeutic targets (Review).
Liver fibrosis is a progressive pathological state characterized by aberrant accumulation of extracellular matrix (ECM), predominantly mediated by activation of hepatic stellate cells (HSCs). If left untreated, this…
International journal of molecular medicine · 2026Understanding the effects of ciprofloxacin on corneal epithelial cells: a study using electric cell-substrate impedance sensing (ECIS) technology.
Ciprofloxacin (CPFX) is a widely used ocular antibiotic, but its effects on ocular surface cells remain unclear. Mechanistic investigations into the efficacy of thymosin beta-4 (Tβ4) as an adjunct to CPFX in treating…
Experimental eye research · 2026Abstracts Selected for Podium Presentations [listed in alphabetical order by presenter]
No abstract available.
Bladder cancer (Amsterdam, Netherlands) · 2026Customizable host and viral transcript enrichment using CRISPR-Cas9 long-read sequencing for characterization of low-to-moderate abundance isoforms.
One of the main challenges of whole transcriptome sequencing is the difficulty in detecting and quantifying low-to-moderate abundance transcripts. Methods that address this are either complicated to scale or customize;…
NAR genomics and bioinformatics · 2026Molecular and Immunohistochemical Analyses of PLIN4 in the Spinal Cord and Brain During the Development of Electroacupuncture-Induced Analgesic Tolerance in Mice.
BackgroundElectroacupuncture (EA) is an important non-pharmacological approach for pain management in veterinary and human medicine. However, electroacupuncture-induced analgesic tolerance (EAT) limits its long-term…
Veterinary medicine and science · 2026Thymosin Alpha-1 Provides Direct Neuroprotection by Engaging the Orexin Receptor HCRTR1 to Suppress Neuronal Necroptosis.
Communication between the immune system and the brain is critical for neuronal health, yet the molecular signals that mediate this crosstalk are not fully understood. Here, we uncover an unexpected and direct…
Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Canine Tear Proteomics: A New Frontier in Veterinary Ophthalmology.
Canine tear proteomics is an emerging field with significant potential for advancing both veterinary ophthalmology and comparative biomedical research. Tears are a readily accessible, non-invasive biofluid that contain…
Veterinary ophthalmology · 2026Proteomic insights into azoospermia: protein differences in testicular tissue between non-obstructive and obstructive azoospermia patients.
Non-obstructive azoospermia (NOA) and obstructive azoospermia (OA) are the main classifications of severe male infertility, but the molecular mechanism of NOA remains poorly understood. This study aimed to identify…
Asian journal of andrology · 2026Peptides for Targeting Chondrogenic Induction and Cartilage Regeneration in Osteoarthritis.
ObjectsOsteoarthritis (OA) is a widespread degenerative joint condition commonly occurring in older adults. Currently, no disease-modifying drugs are available, and safety concerns associated with commonly used…
Cartilage · 2026Paper 32. Performance & Promises: A Social Media Review of Alleged Indications, Risks and Usage of “Peptides” in Musculoskeletal Health
No abstract available.
Orthopaedic journal of sports medicine · 2026The Fallopian tube: Biosensor and dynamic regulator of preimplantation development.
The Fallopian tube (also called the oviduct) provides the physiological site for fertilization and early embryonic development in mammals, yet its role in shaping preimplantation developmental competence remains…
PNAS nexus · 2026Peptides in Regenerative Medicine: A Comprehensive Review of Clinical Applications in Tissue Repair and Chronic Pain Management.
Purpose of reviewThis narrative review summarizes the current evidence on regenerative peptides relevant to chronic pain management, including collagen peptides, body protection compound-157 (BPC-157), thymosin beta-4…
Current pain and headache reports · 2026Recombinant human Thymosin β4 ameliorates experimental colitis and intestinal fibrosis through suppression of mineralocorticoid receptor signaling.
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder characterized by epithelial barrier disruption, persistent mucosal inflammation, and progressive intestinal fibrosis, for which effective therapeutic…
Molecular biomedicine · 2026Peptide Supplements and Their Therapeutic Applications in Sports Medicine.
BackgroundThe peptide supplement market has experienced rapid growth due to marketing claims of enhanced performance and accelerated recovery from musculoskeletal injury. These peptides are increasingly popular with…
The American journal of sports medicine · 2026Hydrogels: current biomedical applications and future directions.
Hydrogels are highly hydrated three-dimensional polymeric network materials that have attracted considerable attention in medical and biomedical fields owing to their favorable chemical modifiability, physical…
Molecular biomedicine · 2026Thymosin β4 alleviates sepsis-associated acute kidney injury by suppressing MAPK signaling pathway.
Sepsis-associated acute kidney injury (SA-AKI) is a common complication in septic patients and is associated with high mortality and progression to chronic kidney disease. Previous studies have demonstrated that…
Clinical science (London, England : 1979) · 2026The identity crisis of cryptic lncRNAs: when non-coding RNAs translate into small peptides.
From a historical perspective, long non-coding RNAs (lncRNAs) represent a relatively short story. However, this story has many plot lines, thrills, twists, and turns that altogether form quite a long saga of its own.…
The EMBO journal · 2026Safety and Efficacy of Approved and Unapproved Peptide Therapies for Musculoskeletal Injuries and Athletic Performance.
Peptides are short chains of amino acids with a unique pharmacological niche between small-molecule drugs and large proteins. Their use in sports medicine is rapidly expanding, driven by patient demand for accelerated…
Sports medicine (Auckland, N.Z.) · 2026Dangers of Injectable Peptides and Other Unregulated "Biohacking" Drugs.
Injectable peptides are increasingly used without prescriptions for cosmetic and athletic enhancement, driven by digital marketing and social media. While evidence-based, FDA-approved peptides like semaglutide and…
Missouri medicine · 202603 FACT BANK
A lab-made peptide based on the actin-binding region of Thymosin β-4 — the part linked to cell movement and repair.
Mostly in animal and cell models: wound closure, tendon/muscle injury, cardiac tissue, corneal healing, and blood-vessel growth.
Regulates actin to promote cell migration and angiogenesis — cells reach and rebuild damaged tissue faster in models.
Often used interchangeably, but TB-500 is marketed as the synthetic fragment, not the full natural Thymosin β-4 protein.
No approved human therapeutic indication. Sold as a research chemical; common in veterinary/equine research discussion.
Banned by WADA as a growth-factor/peptide agent — flagged in several equine and athlete anti-doping cases.