TBTB-500
01 TRENDING TOPICS
02 RESEARCH FEED
Understanding the effects of ciprofloxacin on corneal epithelial cells: a study using electric cell-substrate impedance sensing (ECIS) technology.
Ciprofloxacin (CPFX) is a widely used ocular antibiotic, but its effects on ocular surface cells remain unclear. Mechanistic investigations into the efficacy of thymosin beta-4 (Tβ4) as an adjunct to CPFX in treating…
Experimental eye research · 2026Peptides for Targeting Chondrogenic Induction and Cartilage Regeneration in Osteoarthritis.
ObjectsOsteoarthritis (OA) is a widespread degenerative joint condition commonly occurring in older adults. Currently, no disease-modifying drugs are available, and safety concerns associated with commonly used…
Cartilage · 2026Peptides in Regenerative Medicine: A Comprehensive Review of Clinical Applications in Tissue Repair and Chronic Pain Management.
Purpose of reviewThis narrative review summarizes the current evidence on regenerative peptides relevant to chronic pain management, including collagen peptides, body protection compound-157 (BPC-157), thymosin beta-4…
Current pain and headache reports · 2026Recombinant human Thymosin β4 ameliorates experimental colitis and intestinal fibrosis through suppression of mineralocorticoid receptor signaling.
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder characterized by epithelial barrier disruption, persistent mucosal inflammation, and progressive intestinal fibrosis, for which effective therapeutic…
Molecular biomedicine · 2026Peptide Supplements and Their Therapeutic Applications in Sports Medicine.
BackgroundThe peptide supplement market has experienced rapid growth due to marketing claims of enhanced performance and accelerated recovery from musculoskeletal injury. These peptides are increasingly popular with…
The American journal of sports medicine · 2026Hydrogels: current biomedical applications and future directions.
Hydrogels are highly hydrated three-dimensional polymeric network materials that have attracted considerable attention in medical and biomedical fields owing to their favorable chemical modifiability, physical…
Molecular biomedicine · 2026Thymosin β4 alleviates sepsis-associated acute kidney injury by suppressing MAPK signaling pathway.
Sepsis-associated acute kidney injury (SA-AKI) is a common complication in septic patients and is associated with high mortality and progression to chronic kidney disease. Previous studies have demonstrated that…
Clinical science (London, England : 1979) · 2026The identity crisis of cryptic lncRNAs: when non-coding RNAs translate into small peptides.
From a historical perspective, long non-coding RNAs (lncRNAs) represent a relatively short story. However, this story has many plot lines, thrills, twists, and turns that altogether form quite a long saga of its own.…
The EMBO journal · 2026Safety and Efficacy of Approved and Unapproved Peptide Therapies for Musculoskeletal Injuries and Athletic Performance.
Peptides are short chains of amino acids with a unique pharmacological niche between small-molecule drugs and large proteins. Their use in sports medicine is rapidly expanding, driven by patient demand for accelerated…
Sports medicine (Auckland, N.Z.) · 2026Effects of BPC-157 and TB-500 on Achilles tendon healing in rats: A histopathological and biomechanical study.
ObjectivesThis study aims to evaluate the effects of BPC-157, synthetic thymosin beta-4 (TB-500), and their combination on Achilles tendon healing using biomechanical, histopathological, histochemical, and…
Joint diseases and related surgery · 2026Affibody Complex Formation: An In-Depth Thermodynamic Analysis Using Isothermal Titration Calorimetry.
This study investigates the thermodynamics of binding between the affibody proteins ZTaq and anti-ZTaq across a broad temperature range, aiming to deepen the understanding of the underlying mechanisms governing their…
Molecules (Basel, Switzerland) · 2026Top-Down versus Bottom-Up Proteomics in Highly Sensitive LC-MS-Based Profiling of Limited Samples.
The advantages of top-down proteomics (TDP) in the characterization of proteoforms, resulting from genetic variations, alternative splicing, and post-translational modifications (PTMs), have been well documented.…
Analytical chemistry · 2026[Thymosin β4 inhibits pyroptosis in BV2 microglial cells: a mechanistic study in vitro].
ObjectivesTo investigate the protective effects and molecular mechanisms of thymosin β4 (Tβ4) on pyroptosis in BV2 microglial cells.MethodsBV2 cells were divided into three groups: control group (no treatment),…
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026PEGylated thymosin β4 is a thiol-site-specific prodrug treating myocardial infarction in vivo.
Thymosin beta 4 (Tβ4) has been clinically trialed for over 10 years to treat ulcers, dry eye syndrome, and acute myocardial infarction (MI). However, as of now, no Tβ4 drug has been approved. Tβ4, as a small protein…
Bioengineering & translational medicine · 2026Effects of Supplementation in Masters Athletes and Older Adults: A Narrative Review.
Supplementation use in athletes is common and increasing in popularity, especially for adults seeking improvements in athletic performance. However, the effects of supplementation for older adults or Masters athletes in…
Current sports medicine reports · 2026Ferroptosis in retinal pigment epithelial cells: Current status and future developments.
Retinal pigment epithelial (RPE) cells play a crucial role in maintaining the normal function of the retina. In recent years, research on ferroptosis-a novel iron-dependent form of cell death-in RPE cells has gradually…
Indian journal of ophthalmology · 2026Unregulated Peptide Use in the Age of Biohacking: Digital Promotion, Gray-Market Access, and Emerging Public Health Risks.
Unregulated peptide use is emerging as a digitally mediated public health concern. Although peptide-based medicines have important therapeutic roles when developed, prescribed, manufactured, and monitored through…
Cureus · 2026Biologics for cardiovascular diseases: from bench to bedside.
The rise of biologics, including recombinant proteins, gene therapies, and cell therapies, is reshaping the landscape of modern therapeutics, offering new strategies to address previously "undruggable" targets.…
Signal transduction and targeted therapy · 2026Immune Cell Therapy Promises More Effective Cure for Medulloblastoma.
Medulloblastoma is one of the most prevalent pediatric brain tumors. Currently, existing therapies for this devastating type of cancer can only prolong survival time with severe side-effects and relapse. These therapies…
Journal of personalized medicine · 2026Reparative Outcomes in Corneal Infection: Linking Adjunctive Tβ4 Treatment to Nerve Regeneration and Visual Function.
PurposePrevious studies have shown that adjunctive thymosin beta-4 (Tβ4) with ciprofloxacin reduces bacterial keratitis severity, enhances wound repair, and promotes a return to homeostasis. However, its impact on…
Investigative ophthalmology & visual science · 2026Integrated top-down and bottom-up proteomics enables precise characterization of proteoforms within the protein corona.
Precise characterization of proteoforms within the protein corona is essential for developing safer and more effective nanomedicines for diagnostic and therapeutic applications. Here, we advance the characterization of…
Nature communications · 2026NKX2-1 regulates cell survival, maturation, and DNAdamage responses as a cofactor of RUNX1 in T-cell acute lymphoblastic leukemia.
T-cell acute lymphoblastic leukemia (T-ALL) is characterized by ectopic expression of transcription factors, including NKX2- 1, which is over-expressed in 5% of patients. NKX2-1 is associated with a cortical…
Haematologica · 2026Recombinant Human Thymosin β4 Attenuates Endotoxemia-Induced ALI and EAE by Suppressing Inflammatory and Oxidative Responses
No abstract available.
Biomolecules · 2026Recombinant Human Thymosin β4 Attenuates Endotoxemia-Induced ALI and EAE by Suppressing Inflammatory and Oxidative Responses.
Endotoxemia represents a life-threatening clinical disorder driven by an aberrant host immune response to pathogenic infection, often resulting in severe multiple organ dysfunction. Among its most devastating…
Biomolecules · 202603 FACT BANK
A lab-made peptide based on the actin-binding region of Thymosin β-4 — the part linked to cell movement and repair.
Mostly in animal and cell models: wound closure, tendon/muscle injury, cardiac tissue, corneal healing, and blood-vessel growth.
Regulates actin to promote cell migration and angiogenesis — cells reach and rebuild damaged tissue faster in models.
Often used interchangeably, but TB-500 is marketed as the synthetic fragment, not the full natural Thymosin β-4 protein.
No approved human therapeutic indication. Sold as a research chemical; common in veterinary/equine research discussion.
Banned by WADA as a growth-factor/peptide agent — flagged in several equine and athlete anti-doping cases.