TBTB-500
01 TRENDING TOPICS
02 RESEARCH FEED
Thymosin β4 alleviates sepsis-associated acute kidney injury by suppressing MAPK signaling pathway.
Sepsis-associated acute kidney injury (SA-AKI) is a common complication in septic patients and is associated with high mortality and progression to chronic kidney disease. Previous studies have demonstrated that…
Clinical science (London, England : 1979) · 2026[Thymosin β4 inhibits pyroptosis in BV2 microglial cells: a mechanistic study in vitro].
ObjectivesTo investigate the protective effects and molecular mechanisms of thymosin β4 (Tβ4) on pyroptosis in BV2 microglial cells.MethodsBV2 cells were divided into three groups: control group (no treatment),…
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026Understanding the effects of ciprofloxacin on corneal epithelial cells: a study using electric cell-substrate impedance sensing (ECIS) technology.
Ciprofloxacin (CPFX) is a widely used ocular antibiotic, but its effects on ocular surface cells remain unclear. Mechanistic investigations into the efficacy of thymosin beta-4 (Tβ4) as an adjunct to CPFX in treating…
Experimental eye research · 2026PEGylated thymosin β4 is a thiol-site-specific prodrug treating myocardial infarction in vivo.
Thymosin beta 4 (Tβ4) has been clinically trialed for over 10 years to treat ulcers, dry eye syndrome, and acute myocardial infarction (MI). However, as of now, no Tβ4 drug has been approved. Tβ4, as a small protein…
Bioengineering & translational medicine · 2026Effects of Supplementation in Masters Athletes and Older Adults: A Narrative Review.
Supplementation use in athletes is common and increasing in popularity, especially for adults seeking improvements in athletic performance. However, the effects of supplementation for older adults or Masters athletes in…
Current sports medicine reports · 2026Injuries, Injections, and Internet Forums: A Qualitative Study of Reddit User Perspectives on Peptide Therapy After Orthopaedic Surgery.
No abstract available.
Sports health · 2026Immune Cell Therapy Promises More Effective Cure for Medulloblastoma.
Medulloblastoma is one of the most prevalent pediatric brain tumors. Currently, existing therapies for this devastating type of cancer can only prolong survival time with severe side-effects and relapse. These therapies…
Journal of personalized medicine · 2026Reparative Outcomes in Corneal Infection: Linking Adjunctive Tβ4 Treatment to Nerve Regeneration and Visual Function.
PurposePrevious studies have shown that adjunctive thymosin beta-4 (Tβ4) with ciprofloxacin reduces bacterial keratitis severity, enhances wound repair, and promotes a return to homeostasis. However, its impact on…
Investigative ophthalmology & visual science · 2026NKX2-1 regulates cell survival, maturation, and DNAdamage responses as a cofactor of RUNX1 in T-cell acute lymphoblastic leukemia.
T-cell acute lymphoblastic leukemia (T-ALL) is characterized by ectopic expression of transcription factors, including NKX2- 1, which is over-expressed in 5% of patients. NKX2-1 is associated with a cortical…
Haematologica · 2026Recombinant Human Thymosin β4 Attenuates Endotoxemia-Induced ALI and EAE by Suppressing Inflammatory and Oxidative Responses
No abstract available.
Biomolecules · 2026Recombinant Human Thymosin β4 Attenuates Endotoxemia-Induced ALI and EAE by Suppressing Inflammatory and Oxidative Responses.
Endotoxemia represents a life-threatening clinical disorder driven by an aberrant host immune response to pathogenic infection, often resulting in severe multiple organ dysfunction. Among its most devastating…
Biomolecules · 2026Current State of Orthobiologics in Treatment of Knee Osteoarthritis-Future Directions.
As the population ages, the incidence and prevalence of musculoskeletal degeneration, such as osteoarthritis, increase. While the currently accepted treatment options provide symptomatic and functional improvement, they…
International journal of molecular sciences · 2026Exosomes Released by Cerebrolysin-Treated Cerebral Endothelial Cells Reverse Fibrin- or tPA-Impaired Endothelial Cell Permeability.
Cerebrolysin has a salutary effect on impaired cerebral endothelial cell (CEC) permeability. Using an in vitro endothelial permeability assay, the present study tested the hypothesis that exosomes released by…
Cells · 2026Advances in Living Myocardial Slice Technology for Heart Failure Research.
PurposeThe development of effective treatments for heart failure (HF) often fails due to the lack of preclinical models that closely reflect the native structure and function of the human myocardium. Living myocardial…
Current heart failure reports · 2026SenSet defines cell-type specific senescence signatures in the aged human lung.
Cellular senescence is defined as an irreversible growth arrest observed when cells are exposed to a variety of stressors, including DNA damage, oxidative stress, or nutrient deprivation. Although senescence is a…
The EMBO journal · 2026The hypothalamus is an early site of mitochondrial failure and neuro-immune circuit disruption in amyotrophic lateral sclerosis.
BackgroundMetabolic dysfunction is a defining feature of amyotrophic lateral sclerosis (ALS), emerging early and strongly associated with disease progression and prognosis. While systemic hypermetabolism is well…
Molecular metabolism · 2026Redefining Dry Eye Disease Management: Emerging Pharmacologic and Device-Based Therapies in the Era of Precision Care: A Narrative Review.
Dry eye disease (DED) is a common, chronic ocular condition marked by tear film instability and surface inflammation that impairs comfort, vision, and overall quality of life. In the last decade, major advances have…
Ophthalmology and therapy · 2026Peptide Therapies in Thyroid Health: Emerging Applications in Endocrine and Immune Modulation.
Thyroid disorders, particularly autoimmune conditions such as Hashimoto's thyroiditis, are frequently associated with persistent systemic symptoms despite biochemical normalization with standard hormone replacement,…
Integrative medicine (Encinitas, Calif.) · 2026Proton Irradiation Induces Differential Cellular Responses and Proteomic Signatures in Chondrosarcoma and Chondrocytes.
Chondrosarcoma (CHS), the second most common primary malignant cartilage tumor, is largely resistant to conventional therapies, making surgical resection the standard treatment. Proton therapy offers a physical…
Current issues in molecular biology · 2026Therapeutic Peptides in Aesthetic, Metabolic and Endocrine Conditions: Effects, Safety, Clinical Applications, and Future Perspectives.
Therapeutic peptides are short chains of amino acids used to treat metabolic and endocrine conditions such as obesity and type 2 diabetes. While several peptide drugs have undergone rigorous approval processes that…
International journal of molecular sciences · 2026Comparative analysis of extracellular vesicles released from resting neutrophils under distinct pharmacological inhibition.
Cells in resting conditions spontaneously release extracellular vesicles (EVs). Comparative studies for pharmacological EV inhibition, targeting multiple biogenesis elements within the same cell type, remain scarce.…
Scientific reports · 2026Safety and Efficacy of Approved and Unapproved Peptide Therapies for Musculoskeletal Injuries and Athletic Performance.
Peptides are short chains of amino acids with a unique pharmacological niche between small-molecule drugs and large proteins. Their use in sports medicine is rapidly expanding, driven by patient demand for accelerated…
Sports medicine (Auckland, N.Z.) · 2026Growth Differentiation Factor 9 Supplementation Restores the Lipopolysaccharide-Induced Negative Effects on Bovine Oocyte Developmental Competence.
Growth differentiation factor 9 (GDF9) plays a key role in enhancing developmental competence and blastocyst yield during in vitro maturation (IVM). This study investigated whether GDF9 could counteract the harmful…
Molecular reproduction and development · 2026Elucidating the binding and metabolic interactions of sunitinib and sorafenib with Cytochrome P450s CYP2U1 and CYP2D6.
Cytochrome P450 2U1 (CYP2U1) is an extrahepatic monooxygenase that metabolizes both endogenous fatty acids and xenobiotic substrates. Because of its high expression in both healthy and cancerous thymus tissues, this…
Molecular pharmacology · 202603 FACT BANK
A lab-made peptide based on the actin-binding region of Thymosin β-4 — the part linked to cell movement and repair.
Mostly in animal and cell models: wound closure, tendon/muscle injury, cardiac tissue, corneal healing, and blood-vessel growth.
Regulates actin to promote cell migration and angiogenesis — cells reach and rebuild damaged tissue faster in models.
Often used interchangeably, but TB-500 is marketed as the synthetic fragment, not the full natural Thymosin β-4 protein.
No approved human therapeutic indication. Sold as a research chemical; common in veterinary/equine research discussion.
Banned by WADA as a growth-factor/peptide agent — flagged in several equine and athlete anti-doping cases.